Pharmacovigilance
in one click.
Enter a drug name. Get a complete safety signal profile — adverse events, time-to-onset, and demographic risk — sourced from 1.3 million published case reports, with source citations to back it up.
No account needed. Data from published case reports in the medical literature.
One click.
Complete signal profile.
What used to take a pharmacovigilance team weeks to compile now surfaces in a single query. Run a search to see an empirical, literature-backed safety profile instantly.
Processing Disproportionality
Cross-referencing 1.3M literature reports…
Pembrolizumab
Statistical signal detection from the full published literature.Statistical signal detection from the full published literature.
rxQuery applies established disproportionality analysis methods across 1.3 million published case reports — not just spontaneous reporting databases. Every signal is grounded in documented patient outcomes with traceable source citations.
Proportional Reporting Ratio (PRR)
PrimaryMeasures how often an adverse event occurs with a drug versus all other drugs. PRR ≥ 2 with N ≥ 3 triggers signal review, adapted from WHO-UMC criteria.
Reporting Odds Ratio (ROR)
Case-control analog for secondary confirmation. Lower bound of 95% CI > 1.0 required for signal elevation, adapted from EMA GVP Module IX.
Article Processing Feed
Everything your safety team needs.
A ranked, quantified view of every reported event.
Each adverse event is paired with event frequency, severity classification, time-to-onset distribution, and PRR-weighted signal strength.
Time-to-Onset Patterns
Understand when adverse events typically emerge after drug initiation, enabling proactive monitoring at the right time points.
Bar = median onset relative to treatment duration
Who is most at risk, and when.
Events stratified by sex and age bracket from actual patient profiles in the published literature — not modelled estimates.
Export directly to submission format.
One-click export of structured signal reports in E2B(R3) XML pre-fill format or CSV for further analysis.
Top compounds by adverse event case volume.
Derived directly from 1.3M published case reports.
Click any highlighted compound to run a live signal profile in the interactive demo above.
Case counts derived from published literature case reports. Signal levels correspond to the highest PRR threshold detected for that compound.
Built around the frameworks regulators require.
Every signal generated by rxQuery is structured to align with international pharmacovigilance standards, reducing the manual burden on your regulatory affairs team and simplifying preparation for submission.
EMA & FDA Compatible
Signals formatted to support submission workflows via E2B(R3) individual case safety report pre-fill.
GVP Module IX Aligned
Signal management workflow designed around EMA GVP Module IX principles for detection, evaluation, and prioritisation.
Structured Throughout
All adverse events structured and categorized for compatibility with standard pharmacovigilance terminology systems.
Designed for the teams managing drug safety.
From manual literature trawl to instant signal intelligence.
Your pharmacovigilance scientists currently spend days searching PubMed for adverse event evidence. rxQuery aggregates that evidence continuously, structures it, and surfaces it in one click.
- Continuous signal detection across 1.3M published case reports.
- Pre-built PSUR/PBRER appendix tables ready for submission.
- Literature-sourced signals with full citation traceability.
Fits into your existing safety workflow.
Access your signals & portfolio via our secure web portal, or integrate directly into your existing workflow through our REST API.
Secure by Design
Encrypted in transit and at rest. No patient data leaves your environment.
Safety Database Integration
REST API connects with your existing safety database via authenticated endpoints with full audit logging.
Literature-Based Monitoring
Signal analysis based on published case reports with full citation traceability.
Ready to see your drug's safety profile?
Schedule a 20-minute demo. We'll run a live pharmacovigilance signal report for any compound in your portfolio — right in front of you.